DR. AMBASTA ANITA

Dr. RAKHI KUSUMESH

Abstract

Aim- To elucidate the prevalence and clinical characteristics of AQ4Ab and MOG Ab in atypical optic neuritis in a tertiary eye centre.

Material and method :  Records of  67  patients with atypical  ON  were reviewed . The following data were extracted: medical history, ocular examination, brain, orbital or spinal MRI  ,autoimmune workup . The clinical findings , disease course,and outcomes were compared according to serostatus. Results; 11% ( 7/ 67 ) were positive for MOG antibodies and  9 %( 6/67) were positive for AQP4 antibodies. MOG positive ON  had better visual outcome(p<.05) ,more recurrences (p<.05) than AQP4 positive ON. AQP4 positive ON were more likely to have spinal chord involvement(p<.05). Bilateral involvement with female preponderance was common to both(p>.05). Conclusion- MOG positive ON was more common than AQP4 positive ON. They have distinct phenotypes and outcomes.

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