DR. SUMIT

Dr.Jay Kumar Chhablani

Abstract

We provide an automated OCT based analysis of pigment epithelial detachments (PED) scarring and quantify areas of serous, neovascular, and fibrous tissues in 43 eyes with neovascular AMD. PED were manually segmented, filtered using 2D kernels to create a series of images and pixels within PED classified as serous, neovascular, or fibrous. PEDSI was calculated on per-image basis using relative PED fibrosis areas. Accuracy of segmentation and classification within the PED were graded. Mean overall intra- and inter-observer reproducibility were 0.86±0.07 and 0.86±0.03 respectively. Mean graded scores were 92.12±7.97, 91.48±8.93, and 92.29±8.97 for serous, neovascular and fibrous respectively. Mean total PED area, and when present, mean serous, neovascular, and fibrous areas in mm2 were 0.28±0.41, 0.16±0.36, 0.15±0.20, and 0.06±0.06 respectively. Mean PEDSI was 0.19±0.21. A kernel-based imaging has potential to quantify PED scarring and estimate serous, neovascular, and fibrous tissue.

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