DR. MILY MANDAL

Dr.Sambuddha Ghosh

Abstract

Aim: Diabetes contributes to hepatic microangiopathy, steatosis, and fibrosis. Hepatic steatosis causes oxidative stress, chronic inflammation, and higher insulin resistance which are risk factors for diabetic retinopathy (DR). We assessed the association of DR with hepatic steatosis.

Method: An observational cross-sectional study with 114 middle-aged T2DM patients, 57 with DR and 57 without DR (NODR) was done. Hepatic steatosis index (HSI) was calculated. Hepatic transient elastography was done.

Result: The mean HSI in DR (37.9 ± 3.9) was more (p=.012) than in NODR (36.3± 3.3). Elastography value in DR (6.5±1.8 kPa) was more (p< .001) than in NODR (5.1±1.6 kPa). One unit increase in HSI increases the odds of predicting DR over NODR by 1.356 times. But, there was no association of DR severity with HSI (p=.906). Conclusion: DR is associated with hepatic steatosis in middle-aged T2DM. An early diagnosis of hepatic steatosis in these patients may help to prevent advanced hepatic damage.

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