DR. SOUMI BALA

DR. MD. NAZARUL ISLAM, DR. ASHIS MAJUMDAR

Abstract

BACKGROUND: Epithelial basement membrane dystrophy (EBMD) also called Cogan Microcystic Epithelial Dystrophy is a common bilateral corneal dystrophy. It is an anterior corneal dystrophy presenting with blurred vision and/or corneal erosions and/or foreign body sensation or maybe asymptomatic.

Etiology here includes autosomal dominant inheritance or point mutation in TGFBI gene on chromosome 5(5q31). Risk factors include family history, age, or trauma.

METHODS: It is a hospital based observational case series report conducted at a tertiary center including 8 patients, all of whom belonged to the same family. On Slit-lamp examination dot- like epithelial opacities, whorl like fingerprint lines or circumscribed map like pattern were observed. There is formation of microcysts in corneal epithelium with alterations in basement membrane.

RESULT: Autosomal dominant inheritance of EBMD was noted.