DR. ANAND SHARAN

Dr. RANDHIR KUMAR, Dr.ALKA JHA, DR. ARCHANA SINHA

Abstract

Purpose: To evaluate the efficacy of oral Eplerenone in patients with chronic CSCR.

Methods: All the patients of chronic CSCR treated with oral Eplerenone who had examined for a minimum of 3 months were retrospectively analyzed in a tertiary care hospital. The primary outcome measure was changes in CMT recorded by Spectral-domain OCT & the secondary outcome was changes in SRF, BCVA and the no. of patients achieving complete resolution of SRF.Results: In 15 patients (7M/8F) treated with 25mg &50mg of oral Eplerenone were included. The mean age of follow up was 21±17.6 wks. Mean CMT decreased from 401±133 to 317±75µm at 6 wks & to 285±68µm at 3 months. Mean height of SRF decreased from 157±113 to 78±89µm at 6 wks & to 51±79µm at 3 months. Complete resolution of SRF was found in 9 pts after 3 months. BCVA (logMAR) improved from 0.2±0.18 to 0.14±0.16 at 6 wks & to 0.07±0.13 in 3 months.Conclusion: Eplerenone therapy may improve BCVA & decrease CMT and SRF in patients with chronic CSCR.

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